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Coblyn mouth trial#
We conclude that this trial provides evidence of the short-term efficacy of methotrexate in rheumatoid arthritis, but the mechanism of action is unknown. tonmouth \ kt-n-mauth \ Medical Definition of cottonmouth : water moccasin Test Your Vocabulary Words Named After People Namesake of the leotard, Jules Lotard had what profession Judge Surgeon Firefighter Acrobat Test your visual vocabulary with our 10-question challenge TAKE THE QUIZ A daily challenge for crossword fanatics. Methotrexate did not affect measures of humoral or cellular immunity. One patient died while receiving the placebo. Adverse reactions during methotrexate therapy included transaminase elevation (21 per cent), nausea (18 per cent), and diarrhea (12 per cent) one patient was withdrawn from the trial because of diarrhea. A significantly increased frequency (P less than 0.03) of the HLA-DR2 haplotype occurred in the eight patients with the most substantial response to methotrexate. These variables, as well as the grip strength and erythrocyte sedimentation rate, showed significant (P less than 0.01) improvement at 24 weeks in the population crossed over to methotrexate. The methotrexate group had significant reductions (P less than 0.01 as compared with the placebo group) in the number of tender or painful joints, the duration of morning stiffness, and disease activity according to physician and patient assessments at the 12-week crossover visit reductions in the number of swollen joints (P less than 0.05) and 15-m walking time (P less than 0.03) also occurred. Twenty-eight patients with refractory rheumatoid arthritis completed a randomized 24-week double-blind crossover trial comparing oral methotrexate (2.5 to 5 mg every 12 hours for three doses weekly) with placebo.
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